基因名:
REST
产品别名:
DFNA27; GINGF5; HGF5; NRSF; WT6; XBR; REST; RE1 silencing transcription factor; RE1 silencing transcription factor; RE1-silencing transcription factor; neural-restrictive silencer factor; neuron restrictive silencer factor; repressor binding to the X2 box; 神经元抑制蛋白;
背景信息:
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]