基因名：
RET
产品别名：
CDHF12； CDHR16； HSCR1； MEN2A； MEN2B； MTC1； PTC； RET-ELE1； RET； ret proto-oncogene； ret proto-oncogene； proto-oncogene tyrosine-protein kinase receptor Ret； RET receptor tyrosine kinase； cadherin family member 12； cadherin-related family member 16； proto-oncogene c-Ret； rearranged during transfection； ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)； RET原癌基因； RET原癌基因(RET)； 磷酸化RET原癌基因；
背景信息：
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
