基因名：
ROCK1
产品别名：
P160ROCK； ROCK-I； ROCK1； Rho associated coiled-coil containing protein kinase 1； Rho associated coiled-coil containing protein kinase 1； rho-associated protein kinase 1； p160 ROCK-1； renal carcinoma antigen NY-REN-35； Rho关联含卷曲螺旋结合蛋白激酶1(Rock1)； Rho相关蛋白激酶1； Rho相关蛋白激酶1/2； 磷酸化Rho相关蛋白激酶1；
背景信息：
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq].
