基因名：
RPS6KA2
产品别名：
HU-2； MAPKAPK1C； RSK； RSK3； S6K-alpha； S6K-alpha2； p90-RSK3； p90RSK2； pp90RSK3； RPS6KA2； ribosomal protein S6 kinase A2； ribosomal protein S6 kinase A2； ribosomal protein S6 kinase alpha-2； MAP kinase-activated protein kinase 1c； MAPK-activated protein kinase 1c； mitogen-activated protein kinase-activated protein kinase 1C； ribosomal S6 kinase 3； ribosomal protein S6 kinase, 90kDa, polypeptide 2； 核糖体蛋白S6激酶家族RSK3； 磷酸化核糖体蛋白S6激酶家族RSK3；
背景信息：
RSK3(Ribosomal S6 kinase 3)is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets and may have a unique upstream activator. Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
