位置:首页 > 产品库 > 重组分拣蛋白1(SORT1)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
重组分拣蛋白1(SORT1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

重组分拣蛋白1(SORT1)真核蛋白
Recombinant SORT1
基因名:

SORT1


产品别名:

Gp95; LDLCQ6; NT3; NTR3; SORT1; sortilin 1; sortilin 1; sortilin; 100 kDa NT receptor; glycoprotein 95; neurotensin receptor 3; 分拣蛋白1(SORT1); 分拣蛋白1(SORT1)真核蛋白; 神经降压素受体3/糖蛋白95;


背景信息:
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. Tissue specificity: Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver.
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2025