基因名:
CLEC11A
产品别名:
CLECSF3; LSLCL; P47; SCGF; CLEC11A; C-type lectin domain containing 11A; C-type lectin domain containing 11A; C-type lectin domain family 11 member A; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 3; C-type lectin superfamily member 3; lymphocyte secreted C-type lectin; lymphocyte secreted long form of C-type lectin; osteolectin; stem cell growth factor; stem cell growth factor; lymphocyte secreted C-type lectin; C-型凝集素域家族11成员A(CLEC11A); 干细胞生长因子SCGF;
背景信息:
SCGF is a cytokine for primitive hematopoietic progenitor cells and exhibits species-specific activity. It is predominantly expressed in proliferating chondrocytes, bone marrow cells, the periosteum and the perichondrium of skeletal tissues. SCGF contains an N-terminal Arg-Gly-Asp triplet (RGD triplet), leucine zipper domains, a C-terminal C-type lectin domain and numerous potential glycosylation sites. It has burst-promoting activity and granulocyte/macrophage colony-promoting activity in vitro. SCGF is directly correlated to granulocyte recovery following stem cell transplantation and thus can be an indicator of hematopoietic recovery following stem cell transplantation.