基因名:
SCN1B
产品别名:
ATFB13; BRGDA5; DEE52; EIEE52; GEFSP1; SCN1B; sodium voltage-gated channel beta subunit 1; sodium voltage-gated channel beta subunit 1; sodium channel subunit beta-1; sodium channel, voltage gated, type I beta subunit; sodium channel, voltage-gated, type I, beta; 钠离子通道β1;
背景信息:
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
Tissue specificity; Abundantly expressed in skeletal muscle, heart and brain.