基因名:
CCL3
产品别名:
G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3; CCL3; C-C motif chemokine ligand 3; C-C motif chemokine ligand 3; C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; PAT 464.1; SIS-beta; macrophage inflammatory protein 1-alpha; small inducible cytokine A3 (homologous to mouse Mip-1a); tonsillar lymphocyte LD78 alpha protein; 巨噬细胞炎性蛋白1α; 巨噬细胞炎性蛋白1α(MIP1a); 巨噬细胞炎性蛋白1α(MIP1a)真核蛋白; 巨噬细胞炎症因子1α;
背景信息:
Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.