基因名:
CCL5
产品别名:
D17S136E; RANTES; SCYA5; SIS-delta; SISd; TCP228; eoCP; CCL5; C-C motif chemokine ligand 5; C-C motif chemokine ligand 5; C-C motif chemokine 5; T-cell specific protein p288; beta-chemokine RANTES; chemokine (C-C motif) ligand 5; eosinophil chemotactic cytokine; regulated upon activation, normally T-expressed, and presumably secreted; small inducible cytokine subfamily A (Cys-Cys), member 5; T细胞特异性趋化因子; 调节激活正常T-细胞表达分泌因子(RANTES);
背景信息:
Human Chemokine (C-C Motif) Ligand 5 (CCL5) plays an active role in recruiting leukocytes into inflammatory sites. CCL5 is secreted by many cell types at inflammatory sites and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (AOP)-RANTES exhibit antagonist or partial agonist functions on their receptors. CCL5/RANTES attracts different subtypes of leukocytes into inflamed tissue and intervenes in a wide range of allergic and autoimmune diseases.