基因名：
CCL16
产品别名：
CKb12； HCC-4； ILINCK； LCC-1； LEC； LMC； Mtn-1； NCC-4； NCC4； SCYA16； SCYL4； CCL16； C-C motif chemokine ligand 16； C-C motif chemokine ligand 16； C-C motif chemokine 16； IL-10-inducible chemokine； chemokine (C-C motif) ligand 16； chemokine LEC； liver CC chemokine-1； liver-expressed chemokine； lymphocyte and monocyte chemoattractant； monotactin-1； new CC chemokine 4； small inducible cytokine subfamily A (Cys-Cys), member 16； small-inducible cytokine A16； 巨噬细胞炎性蛋白16； 趋化因子C-C-基元配体16(CCL16)； 趋化因子C-C-基元配体16(CCL16)真核蛋白；
背景信息：
CCL16 is a member of CC chemokine family. CCL16 cDNA encodes a 120 amino acid peptide along with a 23 amino acids signal peptide that is cleaved to generate 97 amino acid protein. CCL16 is distantly related to other CC chemokines, showing less than 30% sequence identity. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8. Recombinant CCL16 has been shown to chemoattract human monocytes and THP1 cells but not resting lymphocytes nor neutrophils. CCL16 has potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. CCL16ninduces a calcium flux in THP1 cells that can be desensitized by prior exposure to RANTES, suggesting that CCL16 and RANTES share the same receptor in THP1 cells.
