基因名：
CCL20
产品别名：
CKb4； Exodus； LARC； MIP-3-alpha； MIP-3a； MIP3A； SCYA20； ST38； CCL20； C-C motif chemokine ligand 20； C-C motif chemokine ligand 20； C-C motif chemokine 20； CC chemokine LARC； beta chemokine exodus-1； chemokine (C-C motif) ligand 20； liver and activation-regulated chemokine； macrophage inflammatory protein 3 alpha； small inducible cytokine subfamily A (Cys-Cys), member 20； small-inducible cytokine A20； 巨噬细胞炎性蛋白3α(MIP3a)； 巨噬细胞炎性蛋白MIP-3a； 巨噬细胞炎性蛋白MIP-3a蛋白；
背景信息：
Chemokine (C-C motif) ligand 2 (CCL2) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA). MIP3A / CCL2 is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of MIP3A / CCL2 has been seen in thymus, prostate, testis, small intestine and colon. As a chemotactic factor, MIP3A / CCL2 attracts lymphocytes and, slightly, neutrophils, but not monocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Its C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Chemokine CCL2 was shown to play a role in colorectal cancer (CRC) pathogenesis.
