基因名：
SELP
产品别名：
CD62； CD62P； GMP140； GRMP； LECAM3； PADGEM； PSEL； SELP； selectin P； selectin P； P-selectin； CD62 antigen-like family member P； GMP-140； granule membrane protein 140； granule membrane protein 140kDa； granulocyte membrane protein； leukocyte-endothelial cell adhesion molecule 3； platelet activation dependent granule-external membrane protein； platelet alpha-granule membrane protein； selectin P (granule membrane protein 140kDa, antigen CD62)； P-Selectin蛋白； P选择素(SELP)； P选择素(SELP)真核蛋白； P选择素/白细胞内皮细胞粘附分子3； 可溶性P选择素；
背景信息：
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. it also mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P-selectin interacts with SNX17, PSGL1/SEPL, PODXL2, mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
