基因名：
SH3GL3
产品别名：
CNSA3； EEN-B2； HsT19371； SH3D2C； SH3P13； SH3GL3； SH3 domain containing GRB2 like 3, endophilin A3； SH3 domain containing GRB2 like 3, endophilin A3； endophilin-A3； SH3 domain containing GRB2 like endophilin A3； SH3 domain protein 2C； SH3 domain-containing GRB2-like protein 3； SH3-domain GRB2-like 3； endophilin-3； 胞浆蛋白SH3GL3；
背景信息：
The endophilins comprise a family of three SH3 domain-containing proteins designated Endophilin I, II and III, or alternatively known as SH3P4, SH3P8 and SH3P13, respectively. These proteins associate with Amphiphysin, Synaptojanin and Dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse, as Endophilin I is ex- pressed only in the brain. Both Endophilin II and Endophilin III are detected in a variety of tissues. Endophilin I is also implicated in modulating G protein-coupled receptor signaling by functioning as an adapter protein and directing 1 adrenergic receptors to the endocytic machinery.
