基因名：
SHC1
产品别名：
SHC； SHCA； SHC1； SHC adaptor protein 1； SHC adaptor protein 1； SHC-transforming protein 1； SH2 domain protein C1； SHC (Src homology 2 domain containing) transforming protein 1； SHC-transforming protein 3； SHC-transforming protein A； SH2结构域转化蛋白1； SHC-转化蛋白1(SHC1)； 磷酸化SH2结构域转化蛋白1；
背景信息：
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
