基因名：
SUMO2
产品别名：
HSMT3； SMT3B； SMT3H2； SUMO3； Smt3A； SUMO2； small ubiquitin like modifier 2； small ubiquitin like modifier 2； small ubiquitin-related modifier 2； SMT3 homolog 2； SMT3 suppressor of mif two 3 homolog 2； sentrin 2； ubiquitin-like protein SMT3A； ubiquitin-like protein SMT3B； 小泛素相关修饰蛋白2(SUMO2)； 泛素样蛋白Sumo2； 泛素样蛋白Sumo2/3；
背景信息：
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
