基因名:
SNCA
产品别名:
NACP; PARK1; PARK4; PD1; SNCA; synuclein alpha; synuclein alpha; alpha-synuclein; I+/--synuclein; non A-beta component of AD amyloid; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor); 核突触蛋白; 核突触蛋白-α; 核突触蛋白-β; 核突触蛋白α+β; 核突触蛋白β/βsynuclein; 硝基化α-突触核蛋白/n-syn; 磷酸化核突触蛋白α; 突触核蛋白α(SNCa);
背景信息:
Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB).