基因名：
DENND2B
产品别名：
HTS1； ST5； p126； DENND2B； DENN domain containing 2B； DENN domain containing 2B； DENN domain-containing protein 2B； DENN/MADD domain containing 2B； heLa tumor suppression 1； suppression of tumorigenicity 5 protein； 抑癌蛋白5；
背景信息：
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008].
