基因名：
ST14
产品别名：
ARCI11； CAP3； HAI； MT-SP1； MTSP1； PRSS14； SNC19； TADG15； TMPRSS14； ST14； ST14 transmembrane serine protease matriptase； ST14 transmembrane serine protease matriptase； suppressor of tumorigenicity 14 protein； channel-activating protein 3； membrane-type serine protease 1； prostamin； serine protease 14； serine protease TADG-15； suppression of tumorigenicity 14 (colon carcinoma)； suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)； tumor associated differentially expressed gene 15 protein； 丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1； 瘤变抑制因子14(ST14)；
背景信息：
MTSP1 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.
