基因名：
STAT1
产品别名：
CANDF7； IMD31A； IMD31B； IMD31C； ISGF-3； STAT91； STAT1； signal transducer and activator of transcription 1； signal transducer and activator of transcription 1； signal transducer and activator of transcription 1-alpha/beta； signal transducer and activator of transcription 1, 91kD； signal transducer and activator of transcription 1, 91kDa； transcription factor ISGF-3 components p91/p84； 信号传导转录激活因子1(STAT1)； 信号转导与转录激活因子1； 磷酸化信号转导与转录激活因子1；
背景信息：
Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.
