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重组信号传导转录激活因子5B(STAT5B)蛋白
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

重组信号转导和转录激活因子5b蛋白
Recombinant STAT5B
基因名:

STAT5B


产品别名:

GHISID2; STAT5; STAT5B; signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B; signal transducer and activator of transcription 5B; transcription factor STAT5B; 信号传导转录激活因子5B(STAT5B); 信号转导和转录激活因子5b; 磷酸化信号转导和转录激活因子5b;


背景信息:
Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.
 
 
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