基因名:
SULT1A1
产品别名:
HAST1/HAST2; P-PST; P-PST 1; PST; ST1A1; ST1A3; STP; STP1; TSPST1; ts-PST; SULT1A1; sulfotransferase family 1A member 1; sulfotransferase family 1A member 1; sulfotransferase 1A1; aryl sulfotransferase 1; phenol-sulfating phenol sulfotransferase 1; sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; thermostable phenol sulfotransferase1; 芳基磺基转移酶1; 苯酚磺基转移酶(SULT1A1);
背景信息:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds.Particularly SULT1A1 (Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1), a member of the sulfotransferase 1 subfamily, which is a major pathway for drug metabolism in humans. Statistically significant associations were observed between the SULT1A1 genotype (Arg213His) and age, obesity and certain neoplasias (mammary, pulmonary, esophageal and urothelial cancer). Furthermore, the polymorphism of the SULT1A1 may be closely associated with breast cancer.