基因名：
SUV39H1
产品别名：
H3-K9-HMTase 1； KMT1A； MG44； SUV39H； SUV39H1； SUV39H1 histone lysine methyltransferase； SUV39H1 histone lysine methyltransferase； histone-lysine N-methyltransferase SUV39H1； Su(var)3-9 homolog 1； histone H3-K9 methyltransferase 1； histone-lysine N-methyltransferase, H3 lysine-9 specific 1； lysine N-methyltransferase 1A； position-effect variegation 3-9 homolog； suppressor of variegation 3-9 homolog 1； 组蛋白H3 K9甲基转移酶；
背景信息：
SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.
