基因名：
TAL1
产品别名：
SCL； TCL5； bHLHa17； tal-1； TAL1； TAL bHLH transcription factor 1, erythroid differentiation factor； TAL bHLH transcription factor 1, erythroid differentiation factor； T-cell acute lymphocytic leukemia protein 1； T-cell acute lymphocytic leukemia 1； T-cell leukemia/lymphoma protein 5； class A basic helix-loop-helix protein 17； stem cell protein； tal-1 product； T-细胞急性淋巴细胞白血病蛋白1(TAL1)； T细胞急性淋巴细胞白血病蛋白1；
背景信息：
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.
