基因名：
TARBP2
产品别名：
LOQS； TRBP； TRBP1； TRBP2； TARBP2； TARBP2 subunit of RISC loading complex； TARBP2 subunit of RISC loading complex； RISC-loading complex subunit TARBP2； TAR (HIV) RNA-binding protein 2； TAR (HIV) RNA-binding protein TRBP1； TAR (HIV-1) RNA binding protein 2； TAR RNA binding protein 2； TARBP2, RISC loading complex RNA binding subunit； trans-activation responsive RNA-binding protein； TRBP蛋白；
背景信息：
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]
