基因名：
ELOB
产品别名：
SIII； TCEB2； ELOB； elongin B； elongin B； elongin-B； RNA polymerase II transcription factor SIII p18 subunit； RNA polymerase II transcription factor SIII subunit B； SIII p18； elongin 18 kDa subunit； elongin, 18-kD subunit； epididymis secretory sperm binding protein； transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)； transcription elongation factor B polypeptide 2； transcription elongation factor B subunit 2； 延伸蛋白B(ELOB)； 转录延伸因子B2；
背景信息：
TCEB2 (Elongin B), is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described.
