基因名：
TGFB3
产品别名：
ARVD； ARVD1； LDS5； RNHF； TGF-beta3； TGFB3； transforming growth factor beta 3； transforming growth factor beta 3； transforming growth factor beta-3 proprotein； prepro-transforming growth factor beta-3； TGF beta 3蛋白； 转化生长因子-β3； 转化生长因子β3(TGFb3)； 转移生长因子β3； 转移生长因子β3（TGFβ3）；
背景信息：
Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.
