基因名：
TIMP2
产品别名：
CSC-21K； DDC8； TIMP2； TIMP metallopeptidase inhibitor 2； TIMP metallopeptidase inhibitor 2； metalloproteinase inhibitor 2； testicular secretory protein Li 57； tissue inhibitor of metalloproteinases 2； 组织金属蛋白酶抑制因子2(TIMP2)； 组织金属蛋白酶抑制因子2(TIMP2)真核蛋白； 金属蛋白酶组织抑制因子-2；
背景信息：
Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid-potentiating and cell growth promoting activities.
