基因名：
TNFRSF1A
产品别名：
CD120a； FPF； TBP1； TNF-R； TNF-R-I； TNF-R55； TNFAR； TNFR1； TNFR55； TNFR60； p55； p55-R； p60； TNFRSF1A； TNF receptor superfamily member 1A； TNF receptor superfamily member 1A； tumor necrosis factor receptor superfamily member 1A； TNF-R1； TNF-RI； TNFR-I； tumor necrosis factor binding protein 1； tumor necrosis factor receptor type 1； tumor necrosis factor-alpha receptor； TNFRSF1A蛋白； 肿瘤坏死因子受体1； 肿瘤坏死因子受体超家族成员1A(TNFR1)；
背景信息：
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) is a member of the tumor necrosis factor receptor superfamily. TNFRSF1A is one of the major receptors for the tumor necrosis factor-alpha. It can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome.
