基因名：
CRISP2
产品别名：
CRISP-2； CT36； GAPDL5； TPX1； TSP1； CRISP2； cysteine rich secretory protein 2； cysteine rich secretory protein 2； cysteine-rich secretory protein 2； cancer/testis antigen 36； glyceraldehyde-3-phosphate dehydrogenase-like 5； testicular tissue protein Li 43； testis specific protein 1 (probe H4-1 p3-1)； testis-specific protein TPX-1； 半胱氨酸丰富分泌蛋白2(CRISP2)； 富含半胱氨酸分泌蛋白2；
背景信息：
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins which may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. CRISP-1 coats the postacrosomal region of sperm heads as they pass through the epididymis. CRISP-1 is found in all regions of the epididymis, ductus deferens, seminal plasma and sperm. CRISP-2, also known as testis-specific protein TPX1 or cancer/testis antigen 36 (CT36), is a 243 amino acid secreted protein. Expressed in the testis and epididymis, CRISP-2 is thought to be involved in calcium fluxes during sperm capacitation by regulating the activity of certain ion channels. CRISP-3 is expressed in pancreas and prostate tissues and, along with CRISP-1, is expressed in saliva. The gene that encodes CRISP-3 is an early response gene that may participate in the pathophysiology of the auto-immune lesions of Sjogren’s syndrome.
