基因名：
TNFSF4
产品别名：
CD134L； CD252； GP34； OX-40L； OX4OL； TNLG2B； TXGP1； TNFSF4； TNF superfamily member 4； TNF superfamily member 4； tumor necrosis factor ligand superfamily member 4； CD134 ligand； OX40 antigen ligand； glycoprotein Gp34； tax-transcriptionally activated glycoprotein 1 (34kD)； tumor necrosis factor (ligand) superfamily member 4； tumor necrosis factor ligand 2B； tumor necrosis factor superfamily member 4； 肿瘤坏死因子配体超家族成员4； 肿瘤坏死因子配体超家族成员4(TNFSF4)； 肿瘤坏死因子配体超家族成员4(TNFSF4)真核蛋白；
背景信息：
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional, it has been found association with systemic lupus erythematosus, no association with occurrence of atherosclerosis.
