基因名：
UMPS
产品别名：
OPRT； UMPS； uridine monophosphate synthetase； uridine monophosphate synthetase； uridine 5'-monophosphate synthase； OMPdecase； OPRTase； UMP synthase； orotate phosphoribosyltransferase； orotidine 5'-phosphate decarboxylase； 尿苷单磷酸合成酶(UMPS)； 尿苷磷酸合成酶；
背景信息：
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
