基因名：
VARS1
产品别名：
G7A； NDMSCA； VARS； VARS2； VARS1； valyl-tRNA synthetase 1； valyl-tRNA synthetase 1； valine--tRNA ligase； protein G7a； valRS； valine tRNA ligase 1, cytoplasmic； valyl-tRNA synthetase 2； 缬氨酰-tRNA合成酶； 缬氨酰-tRNA合成酶1； 缬氨酰tRNA合成酶(VARS)；
背景信息：
ValRS (valyl-tRNA synthetase), also known as Protein G7a, belongs to the class-I aminoacyl-tRNA synthetase family that includes the related proteins, LeuRS and IleRS. These proteins are large monomeric proteins and play a major role in catalyzing the aminoacylation of tRNA by their cognate amino acid. ValRS joins Val to tRNA(Val) at its synthetic active site. At its CP1 editing active site, ValRS hydrolyzes or deacylates tRNA(Thr) that is incorrectly joined to Val. ValRS forms aggregates with EF-1 (elongation factor 1) and, via this complex, catalyzes the aminoacylation of tRNA and its transfer to EF-1. In addition, ValRS may be regulated by PKC-dependent phosphorylation.
