基因名:
VCP
产品别名:
CDC48; FTDALS6; TERA; p97; VCP; valosin containing protein; valosin containing protein; transitional endoplasmic reticulum ATPase; 15S Mg(2+)-ATPase p97 subunit; TER ATPase; 含缬酪肽蛋白; 含缬酪肽蛋白(VCP);
背景信息:
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. VCP participates in the formation of the transitional endoplasmic reticulum (tER) and regulates E3 ubiquitin-protein ligase activity of RNF19A.