基因名：
WT1
产品别名：
AWT1； GUD； NPHS4； WAGR； WIT-2； WT-1； WT33； WT1； WT1 transcription factor； WT1 transcription factor； Wilms tumor protein； Wilms tumor 1； 肾母细胞瘤蛋白； 肾母细胞瘤蛋白1(WT1)；
背景信息：
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
