基因名：
ZAP70
产品别名：
ADMIO2； IMD48； SRK； STCD； STD； TZK； ZAP-70； ZAP70； zeta chain of T cell receptor associated protein kinase 70； zeta chain of T cell receptor associated protein kinase 70； tyrosine-protein kinase ZAP-70； 70 kDa zeta-associated protein； 70 kDa zeta-chain associated protein； syk-related tyrosine kinase； zeta chain of T cell receptor associated protein kinase 70kDa； zeta-chain (TCR) associated protein kinase 70kDa； zeta-chain associated protein kinase, 70kD； 70kDaζ链关联蛋白激酶(zAP70)； zeta相关蛋白70； 磷酸化zeta相关蛋白70；
背景信息：
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
