基因名：
TRIM25
产品别名：
EFP； RNF147； Z147； ZNF147； TRIM25； tripartite motif containing 25； tripartite motif containing 25； E3 ubiquitin/ISG15 ligase TRIM25； RING finger protein 147； RING-type E3 ubiquitin transferase TRIM25； estrogen-responsive finger protein； tripartite motif protein TRIM25； tripartite motif-containing protein 25； ubiquitin/ISG15-conjugating enzyme TRIM25； zinc finger protein 147 (estrogen-responsive finger protein)； zinc finger protein-147； 磷酸化雌激素反应指状蛋白； 雌激素反应锌指蛋白；
背景信息：
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc binding domains, a RING, a B box type 1 and a B box type 2, and a coiled coil region. The protein localizes to the cytoplasm. The presence of potential DNA binding and dimerization transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
