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重组低密度脂蛋白受体相关蛋白8(LRP8)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

重组载脂蛋白E2受体
Recombinant LRP8
基因名:

LRP8


产品别名:

APOER2; HSZ75190; LRP-8; MCI1; LRP8; LDL receptor related protein 8; LDL receptor related protein 8; low-density lipoprotein receptor-related protein 8; ApoE receptor 2; low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; 低密度脂蛋白受体相关蛋白8(LRP8); 载脂蛋白E2受体;


背景信息:
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
 
 
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