基因名：
IL1R2
产品别名：
CD121b； CDw121b； IL-1R-2； IL-1RT-2； IL-1RT2； IL1R2c； IL1RB； IL1R2； interleukin 1 receptor type 2； interleukin 1 receptor type 2； interleukin-1 receptor type 2； CD121 antigen-like family member B； IL-1 type II receptor； IL-1R-beta； antigen CDw121b； interleukin-1 receptor beta； interleukin-1 receptor type II； type II interleukin-1 receptor, beta； 白介素1受体2； 白介素1受体Ⅱ(IL1R2)；
背景信息：
Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signaling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
