基因名：
CXCR4
产品别名：
CD184； D2S201E； FB22； HM89； HSY3RR； LAP-3； LAP3； LCR1； LESTR； NPY3R； NPYR； NPYRL； NPYY3R； WHIM； WHIMS； WHIMS1； CXCR4； C-X-C motif chemokine receptor 4； C-X-C motif chemokine receptor 4； C-X-C chemokine receptor type 4； CD184 antigen； LPS-associated protein 3； SDF-1 receptor； chemokine (C-X-C motif) receptor 4； fusin； leukocyte-derived seven transmembrane domain receptor； lipopolysaccharide-associated protein 3； neuropeptide Y receptor Y3； neuropeptide Y3 receptor； seven transmembrane helix receptor； seven-transmembrane-segment receptor, spleen； stromal cell-derived factor 1 receptor； 磷酸化细胞表面趋化因子受体4； 细胞表面趋化因子受体4； 趋化因子C-X-C-基元受体4(CXCR4)；
背景信息：
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
