基因名：
USP7
产品别名：
HAFOUS； HAUSP； TEF1； USP7； ubiquitin specific peptidase 7； ubiquitin specific peptidase 7； ubiquitin carboxyl-terminal hydrolase 7； Herpes virus-associated ubiquitin-specific protease； deubiquitinating enzyme 7； ubiquitin specific peptidase 7 (herpes virus-associated)； ubiquitin specific protease 7 (herpes virus-associated)； ubiquitin thioesterase 7； ubiquitin-specific-processing protease 7； 泛素特异性肽酶7(USP7)；
背景信息：
USP7 is a cysteine protease, belongs to the family of ubiquitin-specific proteases. USP7 was first discovered as a binding enzyme to the Herpes simplex viral protein. Studies have shown that USP7 could deubiquitinate the autoubiquitination of an E3 ligase called HDM2 that promotes ubiquitination and subsequent degradation of p53. The USP7/HDM2/p53 interaction results in higher protein levels of HDM2 and lower levels of p53. Because of its apparent role in different types of pathologies, including lung and liver cancer, it has become a possible target for drug therapies.
