基因名：
SHOC2
产品别名：
NSLH1； SIAA0862； SOC2； SUR8； SHOC2； SHOC2 leucine rich repeat scaffold protein； SHOC2 leucine rich repeat scaffold protein； leucine-rich repeat protein SHOC-2； soc-2 suppressor of clear homolog； 富含亮氨酸重复蛋白SHOC2；
背景信息：
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
