Semapimod tetrahydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	164301-51-3
规格:	≥98%

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

Semapimod 4HCl, the tetrahydrochloride salt of Semapimod mesylate (AXD 455; AIDS-121302; CNI-1493), is a novel and potent cytokine inhibitor that inhibits the production of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. It also inhibits TLR4 signaling (IC50≈0.3 μM) and p38 MAPK and nitric oxide production in macrophages. As an investigational new drug, Semapimod has anti-inflammatory, anti-cytokine, immunomodulatory, antiviral and antimalarial properties. Structurally, semapimod is synthetic guanylhydrazone mitogen-activated protein kinase blocker, as a potential treatment for Crohn's disease and other inflammatory conditions.

理化性质和储存条件

Molecular Formula: C34H52N18O2;

Molecular Weight: 744.9;

Exact Mass: 744.45206;

Synonym: CNI1493; AXD455; AIDS121302; CNI-1493; AXD 455; AIDS-121302; CNI1493; AXD-455; Semapimod HCl.

Chemical Name: N1,N10-bis(3-(1-(2-carbamimidoylhydrazono)ethyl)-5-(1-(2-carbamimidoylhydrazono)ethyl)phenyl)decanediamide, tetrahydrochloride

InChi Key: MAHASPGBAIQZLY-RTQZJKMDSA-N

InChi Code: InChI=1S/C34H52N18O2.4ClH/c1-19(45-49-31(35)36)23-13-24(20(2)46-50-32(37)38)16-27(15-23)43-29(53)11-9-7-5-6-8-10-12-30(54)44-28-17-25(21(3)47-51-33(39)40)14-26(18-28)22(4)48-52-34(41)42;;;;/h13-18H,5-12H2,1-4H3,(H,43,53)(H,44,54)(H4,35,36,49)(H4,37,38,50)(H4,39,40,51)(H4,41,42,52);4*1H/b45-19+,46-20+,47-21+,48-22+;;;;

SMILES Code: O=C(NC1=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C1)CCCCCCCCC(NC2=CC(/C(C)=N/NC(N)=N)=CC(/C(C)=N/NC(N)=N)=C2)=O.[H]Cl.[H]Cl.[H]Cl.[H]Cl