基因名：
GDF5
产品别名：
BDA1C； BMP-14； BMP14； CDMP1； DUPANS； LAP-4； LAP4； OS5； SYM1B； SYNS2； GDF5； growth differentiation factor 5； growth differentiation factor 5； growth/differentiation factor 5； LPS-associated protein 4； bone morphogenetic protein 14； cartilage-derived morphogenetic protein-1； lipopolysaccharide-associated protein 4； radotermin； 生长分化因子5(GDF5)； 软骨衍生形态发生蛋白1/GDF 5；
背景信息：
Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.
