基因名：
AXIN2
产品别名：
AXIL； ODCRCS； AXIN2； axin 2； axin 2； axin-2； axin-like protein； axis inhibition protein 2； conductin； Axis抑制蛋白2(AXIN2)； 轴抑制蛋白2；
背景信息：
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
