基因名:
ENC1
产品别名:
CCL28; ENC-1; KLHL35; KLHL37; NRPB; PIG10; TP53I10; ENC1; ectodermal-neural cortex 1; ectodermal-neural cortex 1; ectoderm-neural cortex protein 1; ectodermal-neural cortex 1 (with BTB domain); ectodermal-neural cortex 1 (with BTB-like domain); kelch-like 35; kelch-like family member 37; kelch-like protein 37; nuclear matrix protein NRP/B; nuclear restricted protein, BTB domain-like (brain); p53-induced gene 10 protein; tumor protein p53 inducible protein 10; 外胚层神经皮层蛋白1/KLHL35;
背景信息:
Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. May be down-regulated in neuroblastoma tumors. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Tissue specificity: Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas.