基因名：
MADD
产品别名：
DEEAH； DENN； IG20； NEDDISH； RAB3GEP； RabGEF； MADD； MAP kinase activating death domain； MAP kinase activating death domain； MAP kinase-activating death domain protein； Rab3 GDP/GTP exchange factor； differentially expressed in normal and neoplastic cells； insulinoma glucagonoma clone 20； rab3 GDP/GTP exchange protein； MAP激酶激活的死亡域蛋白(MADD)； 死亡结构域接头蛋白DENN；
背景信息：
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
