基因名：
PLPP3
产品别名：
Dri42； LPP3； PAP2B； PPAP2B； VCIP； PLPP3； phospholipid phosphatase 3； phospholipid phosphatase 3； phospholipid phosphatase 3； PAP2 beta； lipid phosphate phosphohydrolase 3； phosphatidate phosphohydrolase type 2b； phosphatidic acid phosphatase type 2B； type-2 phosphatidic acid phosphatase-beta； vascular endothelial growth factor and type I collagen inducible； 磷脂酸磷酸酶2b；
背景信息：
Phosphatidic acid phosphatase type 2b (PPAP2b) is a member of the phosphatidic acid phosphatase (PAP) family that function in de novo synthesis of glycerolipids as well as in receptor activated signal transduction mediated by phospholipase D. PAP2b catalyzes the conversion of phosphatidic acid to diacylglycerol and hydrolyzes lysophosphatidic acid, ceramide-1-phosphate and sphingosine-1-phosphate. It is a homodimer glycoprotein localized at the cell plasma membrane. Expression promotes adhesion, spreading, and tyrosine phosphorylation of Fak, Shc, Cas and paxillin in endothelial cells. PAP2b induced cell-cell interactions regulate specific intracellular signaling pathways that involve p120-catenin, Fak, Akt, and GSK3? protein kinases.
