基因名：
ABCB11
产品别名：
ABC16； BRIC2； BSEP； PFIC-2； PFIC2； PGY4； SPGP； ABCB11； ATP binding cassette subfamily B member 11； ATP binding cassette subfamily B member 11； bile salt export pump； ABC member 16, MDR/TAP subfamily； ATP-binding cassette sub-family B member 11； ATP-binding cassette, sub-family B (MDR/TAP), member 11； progressive familial intrahepatic cholestasis 2； sister p-glycoprotein； ATP结合盒转运蛋白B11(ABCB11)； 胆汁酸盐输出泵/ATP结合盒转运蛋白11；
背景信息：
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extra- and intracellular membranes through the energy of ATP hydrolysis. ABC genes comprise seven subfamilies, designated ABC1, Mdr/TAP, MRP, ALD, OABP, GCN20 and White. The secretion of bile salt molecules from blood into bile is a major driving force for bile formation. Bile salt export pump (BSEP) is a member of the Mdr/TAP subfamily of ABC transporters that mediates the transport of bile acids across the hepatocyte canalicular membrane and regulates bile acid-dependent bile secretion. BSEP contains putative phosphorylation sites for protein kinase A, protein kinase C (PKC) and Ca2+-calmodulin dependent kinase II, whose regulation may be dependent on bile salt concentration.
