基因名：
SOCS1
产品别名：
AISIMD； CIS1； CISH1； JAB； SOCS-1； SSI-1； SSI1； TIP-3； TIP3； SOCS1； suppressor of cytokine signaling 1； suppressor of cytokine signaling 1； suppressor of cytokine signaling 1； JAK binding protein； STAT induced SH3 protein 1； STAT-induced STAT inhibitor 1； Tec-interacting protein 3； cytokine-inducible SH2 protein 1； 细胞因子信号传导抑制蛋白1； 细胞因子信号转导抑制因子1(SOCS1)；
背景信息：
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor(LIF). Regulates interferon-gamma mediated sensory neuron survival. Implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. High expression in thymus. Lower expression in lung and spleen.
