基因名：
EIF3B
产品别名：
EIF3-ETA； EIF3-P110； EIF3-P116； EIF3S9； PRT1； EIF3B； eukaryotic translation initiation factor 3 subunit B； eukaryotic translation initiation factor 3 subunit B； eukaryotic translation initiation factor 3 subunit B； eukaryotic translation initiation factor 3 subunit 9； eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)； eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa； protein synthesis 1； prt1 homolog； eIF3B蛋白；
背景信息：
eIF3b expression relates to human bladder and prostate cancer prognosis, is required for tumor growth, and thus a candidate therapeutic target.The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.
